EXPERIMENTALLY VALIDATED OXIDATIVE STRESS -ASSOCIATED PROGNOSTIC SIGNATURES DESCRIBE THE IMMUNE LANDSCAPE AND PREDICT THE DRUG RESPONSE AND PROGNOSIS OF SKCM

BackgroundSkin Cutaneous Melanoma (SKCM) incidence is continually increasing, with chemotherapy and immunotherapy being among the most common cancer treatment modalities.This study aims to identify novel biomarkers for chemotherapy and immunotherapy response in SKCM and explore their association with oxidative stress.MethodsUtilizing TCGA-SKCM RNA-

Hive products, encompassing honey, propolis, bee venom, royal jelly, and pollen, are recognized for their antimicrobial and therapeutic properties.This review examines their chemical composition, explores their mechanisms of action, and discusses their potential Clearance applications in both human and veterinary medicine, particularly in addressin

We investigate, both theoretically and experimentally, spatial soliton interaction with dielectric interfaces in a strongly anisotropic medium with non-locality, such as nematic liquid crystals.We throw light on the role of refractive index gradients as well as optic axis variations in both voltage- and self-driven angular steering Push Along Toy o

Apoptosis is an important defense mechanism mounted by the immune system to Posters control virus replication.Hence, cytomegaloviruses (CMV) evolved and acquired numerous anti-apoptotic genes.The product of the human CMV (HCMV) UL36 gene, pUL36 (also known as vICA), binds to pro-caspase-8, thus inhibiting death-receptor apoptosis and enabling viral

The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a Push Along Toy range of biological processes.Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed.Having a selective small molecule tool Posters to interrogate this kinase will help demonstrate th